Clinical Performance of Two Highly Sensitive Cardiac Troponin I Assays
نویسندگان
چکیده
منابع مشابه
Clinical performance of two highly sensitive cardiac troponin I assays.
BACKGROUND The aim of this study was to compare the clinical performance of 2 sensitive cTnI assays with 10% CV imprecision below the 99th percentile upper reference limit. METHODS We measured cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in a random sample of the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV cohort (n = 1251...
متن کاملHighly sensitive cardiac troponin I assay leads to lowered specificity.
I read with great interest the article of Kavsak et al. (1 ) on the utility of a next-generation high-sensitivity Beckman Coulter cardiac troponin I (cTnI) assay with a 20% CV at 2.95 ng/L. This approach demonstrated a higher diagnostic sensitivity (81% vs 62%) for myocardial injury with a changing pattern of cTnI values, compared with the AccuTnI assay cleared by the US Food and Drug Administr...
متن کاملSensitive cardiac troponin assays: sense and sensibility.
To meet the criteria defined in the universal definition of acute myocardial infarction (AMI), sensitive assays for cardiac troponins I and T have recently been introduced into clinical medicine. Such assays are commonly understood to have a detection limit ,99th percentile of a reference population and a total imprecision at the 99th percentile ≤10%. The analytical performance of these assays,...
متن کاملThe antibody configurations of cardiac troponin I assays may determine their clinical performance.
BACKGROUND Previous studies have shown superior clinical performance of the cardiac troponin I (cTnI) assay from Beckman-Coulter Diagnostics. This assay had a unique combination of monoclonal antibodies with 2 monoclonal antibodies directed against epitopes near the NH(2) terminus of the heart-specific region of troponin I. The approach has been adopted by the new cTnI assay from Abbott Diagnos...
متن کاملDegradation of cardiac troponin I in serum complicates comparisons of cardiac troponin I assays.
BACKGROUND Up to a 20-fold variation in serum cardiac troponin I (cTnI) concentration may be observed for a given patient sample with different analytical methods. Because more limited variation is seen for control materials and for purified cTnI, we explored the possibility that cTnI was present in altered forms in serum. METHODS We used four recombinantly engineered cTnI fragments to study ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2009
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2008.106500